Peyraud R, Dubiella U, Barbacci A, Genin S, Raffaele S, Roby D. Advances on plant-pathogen interactions from molecular toward systems biology perspectives. Plant J. 2016 Nov 21.
From the abstract: We highlight systems biology as a promising approach to reveal properties of molecular plant pathogen interactions and predict the outcome of such interactions. We first illustrate a few key concepts in plant immunity with a network and systems biology perspective. Next, we present some basic principles of systems biology and show how they allow integrating multi-omics data and predict cell phenotypes. We identify challenges for systems biology of plant-pathogen interactions, including the reconstruction of multiscale mechanistic models and the connection of host and pathogen models. Finally, we outline studies on resistance durability through the robustness of immune system networks, the identification of trade-offs between immunity and growth and in silico plant-pathogen co-evolution as exciting perspectives in the field. |