Surface frustration re-patterning underlies the structural landscape and evolvability of fungal orphan candidate effectors
Our study on the structural landscape and structural evolution of fungal effectors is out in Nature Communications. Together with Mark Derbyshire from the CCDM at Curtin University, Perth, we compared predicted structures for >4000 secreted proteins produced by Ascomycete fungi of diverse lifestyles. We used in silico mutation scans and ancestral structure reconstruction to reveal patterns of evolution in broadly conserved families of proteins. We found that the evolution of these families oscillate around two trajectories: either changing the conformation of surface loops or building up energetic conflicts without structural change. We expect energetic conflicts in folded proteins to increase the propensity to interact with other proteins, a principle known as energetic frustration. Read the full article here:
Surface frustration re-patterning underlies the structural landscape and evolvability of fungal orphan candidate effectors
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